Motif ID: MEF2{A,B,C,D}.p2

Z-value: 7.261


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MEF2Dhg19_v1_chr1_-_156470565_1564705720.663.6e-05Click!
MEF2Ahg19_v1_chr15_+_100106179_1001062100.602.9e-04Click!
MEF2Chg19_v1_chr5_-_88119604_881197430.336.7e-02Click!
MEF2BNB-MEF2Bhg19_v1_chr19_-_19303222_19303399-0.327.1e-02Click!
MEF2Bhg19_v1_chr19_-_19281062_19281073-0.271.4e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_123957941 90.362 NM_001251987
NM_006073
 TRDN

triadin

chr11_-_19223516 79.111 NM_001127656
NM_003476
 CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr7_-_113559048 76.510 NM_002711
 PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr10_+_69869249 75.332 NM_032578
 MYPN
myopalladin
chr17_+_37821598 71.056 NM_003673
 TCAP
titin-cap (telethonin)
chr12_-_111358353 70.781 NM_000432
 MYL2
myosin, light chain 2, regulatory, cardiac, slow
chrX_-_21776158 63.383 NM_014332
 SMPX
small muscle protein, X-linked
chr2_+_88367298 59.452 NM_198274
 SMYD1
SET and MYND domain containing 1
chr2_-_211168315 55.023 NM_079422
 MYL1
myosin, light chain 1, alkali; skeletal, fast
chr10_-_75415748 54.433 NM_001114133
 SYNPO2L
synaptopodin 2-like
chr3_+_121312169 53.214 NM_016298
 FBXO40
F-box protein 40
chr3_-_39234071 53.201 NM_194293
NM_001198621
 XIRP1

xin actin-binding repeat containing 1

chr2_+_168043792 50.502 NM_001199144
NM_001199145
 XIRP2

xin actin-binding repeat containing 2

chr3_+_42727010 49.747 NM_152393
 KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr14_-_23877480 49.419 NM_002471
 MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr10_-_75410778 45.746 NM_024875
 SYNPO2L
synaptopodin 2-like
chr4_-_65275000 44.505 NM_001010874
 TECRL
trans-2,3-enoyl-CoA reductase-like
chr12_+_81101407 43.527 NM_002469
 MYF6
myogenic factor 6 (herculin)
chr18_-_3219986 41.664 NM_003803
NM_019856
 MYOM1

myomesin 1, 185kDa

chr16_-_31439650 38.525 NM_005205
 COX6A2
cytochrome c oxidase subunit VIa polypeptide 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
14.30 1.95e-02 GO:0045214 sarcomere organization
13.48 1.01e-05 GO:0030239 myofibril assembly
12.75 2.18e-10 GO:0030049 muscle filament sliding
12.75 2.18e-10 GO:0033275 actin-myosin filament sliding
12.42 3.50e-10 GO:0070252 actin-mediated cell contraction
11.65 7.85e-06 GO:0031032 actomyosin structure organization
11.05 8.15e-08 GO:0006941 striated muscle contraction
10.01 5.52e-03 GO:0006942 regulation of striated muscle contraction
9.44 4.13e-02 GO:0003015 heart process
9.44 4.13e-02 GO:0060047 heart contraction
9.25 4.92e-08 GO:0030048 actin filament-based movement
6.77 1.98e-17 GO:0003012 muscle system process
6.62 3.25e-02 GO:0048644 muscle organ morphogenesis
6.42 4.07e-03 GO:0055002 striated muscle cell development
6.37 5.49e-14 GO:0006936 muscle contraction
6.29 1.59e-03 GO:0055001 muscle cell development
5.97 2.78e-03 GO:0048738 cardiac muscle tissue development
5.58 5.53e-03 GO:0009408 response to heat
5.38 1.12e-03 GO:0090257 regulation of muscle system process
5.30 3.72e-11 GO:0007517 muscle organ development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
23.59 3.26e-02 GO:0043230 extracellular organelle
23.59 3.26e-02 GO:0065010 extracellular membrane-bounded organelle
20.97 3.77e-03 GO:0031430 M band
17.97 8.57e-03 GO:0005861 troponin complex
16.93 1.21e-05 GO:0031672 A band
15.73 3.56e-08 GO:0016460 myosin II complex
15.73 3.08e-07 GO:0005859 muscle myosin complex
15.73 2.07e-04 GO:0014704 intercalated disc
15.73 2.07e-04 GO:0044291 cell-cell contact zone
13.98 8.61e-06 GO:0032982 myosin filament
13.98 2.93e-02 GO:0005916 fascia adherens
11.55 1.35e-26 GO:0030017 sarcomere
11.39 5.88e-31 GO:0030016 myofibril
11.13 5.80e-29 GO:0044449 contractile fiber part
10.76 2.03e-08 GO:0030018 Z disc
10.74 9.79e-30 GO:0043292 contractile fiber
10.48 2.05e-10 GO:0031674 I band
8.28 5.42e-05 GO:0016528 sarcoplasm
7.86 2.77e-08 GO:0016459 myosin complex
7.65 4.59e-04 GO:0016529 sarcoplasmic reticulum

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
31.45 1.13e-02 GO:0051371 muscle alpha-actinin binding
15.73 2.27e-02 GO:0042805 actinin binding
10.97 6.79e-10 GO:0008307 structural constituent of muscle
3.51 4.14e-08 GO:0003779 actin binding
3.05 7.32e-10 GO:0008092 cytoskeletal protein binding